Diagnostic accuracy of interferon-gamma release assay and mucosal-associated invariant T cells in spinal tuberculosis.

ABSTRACT: Conventional diagnostic methods for tuberculous spondylodiscitis (TS) require tissue biopsy, which can delay diagnosis. Immunodiagnostic approaches, including interferon-gamma release assays (IGRAs), have shown potential for improving TS diagnosis. Recent advancements have also identified the potential role of mucosal-associated invariant T (MAIT) cells as biomarkers for TB infection. This study aims to evaluate the diagnostic performance of IGRA using the QuantiFERON-TB Gold In-Tube test (QFT-GIT) and MAIT cell analysis for diagnosing TS. Sixty-five patients suspected TS were prospectively enrolled, of whom 24 (37%) were categorized as confirmed TS. QFT-GIT demonstrated a sensitivity of 82.61% and specificity of 77.78%. No significant differences were found in the proportion of MAIT cells

SUBMITTER: Mekariya K 

PROVIDER: S-EPMC12615657 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature