Identifying SUMOylation-related genes in liver fibrosis with bioinformatics and experimental models for diagnostic insights.

ABSTRACT: Liver fibrosis (LF) is a medical disorder caused by prolonged chronic liver injury, which, if left untreated, can progress to cirrhosis or liver cancer, posing significant risks to patient health. In recent years, the increase in liver diseases, including alcoholic liver disease, non-alcoholic fatty liver disease, and viral hepatitis, has significantly heightened the prevalence of LF. SUMOylation, an important post-translational modification, is essential for regulating cellular functions and may play a critical role in the progression of LF; however, its exact mechanisms remain poorly understood. This study conducted a thorough examination of the expression patterns of SUMOylation-related genes in patients with LF for the first time. We obtained two LF datasets (GSE130970 and GSE84044) fr

SUBMITTER: Su Z 

PROVIDER: S-EPMC12615703 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature