Vascularization of neonatal liver lobules presages adult liver size.

ABSTRACT: Organs vary in size between and within species to match organismal needs. Theoretical work has proposed that scaling of organs and body parts relies on energy-transport systems, the vascular system in mammals. Here, we use quantitative clonal mapping and volumetric imaging combined with novel molecular and genetic tools to identify temporal and spatial constraints that establish mouse liver size. We find that adult liver size is foreshadowed during a neonatal period when functional units, termed lobules, initiate growth. Nascent lobules are vascularized by prominent sprouting angiogenesis of the hepatic vein, restricted to the periphery of the organ. When Wnt signals are ablated in the single cell-layered mesothelium at the periphery, neonatal growth is disturbed, and the liver adopts a co

SUBMITTER: Azizoglu DB 

PROVIDER: S-EPMC12615705 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature