Differential impacts of interstitial lung disease and airway disease on rheumatoid arthritis disease activity and infection.

ABSTRACT: We aimed to distinguish the individual effects of interstitial lung disease (ILD) and airway disease (AD) on rheumatoid arthritis (RA) disease activity and infection. RA patients who underwent chest CT at Kanazawa University Hospital (2011-2021) were investigated. The primary outcome was infection-related hospitalization, and the secondary was RA disease activity (DAS28-CRP, SDAI) at final observation. Of 569 patients, 125 (22.0%) had ILD (ILD +), and 171 (30.1%) had AD (AD +). At first CT: RA disease activity was similar; ILD + received less methotrexate than ILD-; all DMARDs were similar in AD + and AD-. At final observation (mean: 73.9 months): RA disease activity was higher in ILD + and AD + . Analysis of covariance revealed a significant association between final RA disease activity a

SUBMITTER: Yoshida M 

PROVIDER: S-EPMC12615712 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature