Global research trends and therapeutic potential of fibrinolytic enzymes.

ABSTRACT: Fibrinolytic enzymes are proteolytic enzymes that degrade fibrin clots. They play a significant role in managing thrombosis as they are crucial for the lysis of the clot. Despite the importance and extensive research on fibrinolytic enzymes, many have not been translated into therapeutics due to challenges such as immunogenicity, bleeding risks, and short half-life. Consequently, in this review, a comprehensive assessment was conducted to identify trends and gaps in fibrinolytic enzyme research, analyzing data spanning eight decades alongside important biotechnological discoveries, such as recombinant DNA technology and tissue plasminogen activators, to gain an in-depth understanding of this evolving research area. The field's multidisciplinary nature encompasses medicine, biochemistry, ge

SUBMITTER: Hazare C 

PROVIDER: S-EPMC12615729 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature