Effectiveness of Bioactive Glass-Based Toothpaste for Early Childhood Caries Prevention: A Randomized Controlled Trial.

ABSTRACT:

Aim

Early childhood caries (ECC) remains a significant global health challenge. While fluoride-based treatments are the standard, bioactive glass (BAG) has emerged as a promising alternative for caries prevention. This clinical trial aimed to evaluate the effectiveness of a fluoride-free BAG-based toothpaste compared to a fluoride toothpaste in preventing ECC.

Methods

This double-blinded, multicentre, randomized controlled trial enrolled 1063 children aged 3 to 4 years from 12 kindergartens in Hubei, China. Participants were randomly assigned to either the test (fluoride-free toothpaste containing 7.5% (w/w) BAG) or the control (fluoride toothpaste containing 800 ppm F) group. The primary outcomes were caries increment, measured as changes in decayed, missing, and filled tee

SUBMITTER: Li T 

PROVIDER: S-EPMC12615736 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature