TAF15 in tumor-associated macrophages enhances protumorigenic polarization and promotes cholangiocarcinoma progression.

ABSTRACT:

Background & aims

Intrahepatic cholangiocarcinoma (ICC) is a highly malignant and aggressive cancer. Tumor-associated macrophages (TAMs) are integral to the tumor microenvironment (TME), where they facilitate the malignant progression of ICC and reshape the TME. TATA-binding protein-associated factor 15 (TAF15), a protein that binds both DNA and RNA, plays a pivotal role in inflammatory signaling pathways and is abnormally expressed in TAMs in ICC. However, the specific function of TAF15 in ICC-associated macrophages remains to be elucidated. This study aimed to investigate the regulatory effect of TAF15 in ICC-associated macrophages on ICC progression.

Methods

The expression pattern of TAF15 in macrophages was assessed using multicolor fluorescence in ICC mouse tissues and

SUBMITTER: Liu Y 

PROVIDER: S-EPMC12615741 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature