Hepatocyte iron suppresses liver fibrosis via fibrolytic neutrophil recruitment in cholestasis.

ABSTRACT:

Background & aims

Although it is well documented that iron promotes hepatocyte death in chronic liver disease, recent studies have suggested that iron in hepatocytes also has a protective role against such disease. However, the mechanisms underlying this beneficial role of iron remain poorly understood.

Methods

F-box and leucine-rich repeat protein 5 (FBXL5) is a substrate recognition component of the SCF E3 ligase complex that restricts intracellular iron levels. To investigate the role of hepatic iron in the pathogenesis of cholestatic liver disease, liver-specific FBXL5-deficient or control mice were fed a diet supplemented with 3,5-diethoxycarbonyl-1,4-dihydrocollidine (n = 3-12). Moreover, matrix metalloproteinase (MMP)-9 expression and liver fibrosis were analyzed in l

SUBMITTER: Kanamori Y 

PROVIDER: S-EPMC12615750 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature