Geographical variations in metal exposure and metabolic disorders in Chile using an exposome approach.

ABSTRACT: Exposure to metals may disrupt metabolic pathways, contributing to metabolic disorders. Local environmental factors may modulate these effects, emphasizing the importance of territorial disaggregation. This population-based study evaluated geographic variations in exposure to four metals and their associations with obesity, diabetes, metabolic syndrome, and hypertension in Chile. Data from 3,822 participants in the National Health Survey (2016-17) were analyzed. Biomarkers included inorganic arsenic (As), cadmium (Cd), mercury (Hg) in urine, and lead (Pb) in serum. Metal exposure categories were defined according to the median (50th percentile) distribution, contrasting participants above versus below this threshold. Associations between metal exposure and comorbidities were estimated usin

SUBMITTER: Matus P 

PROVIDER: S-EPMC12615788 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature