A digital twin-enhanced decision support system improves time-in-range in type 1 diabetes: a randomized clinical trial.

ABSTRACT: Most individuals with type 1 diabetes (T1D) worldwide continue to be managed with multiple daily injections or sensor-augmented pumps. Decision-support systems (DSSs) have emerged as cost-effective tools to enhance treatment adherence and glucose control. We conducted a randomized, open-label, parallel-group study to evaluate STUDIA, a DSS incorporating a digital twin-enabled simulation-assisted bolus calculator. Twenty-eight participants with T1D used either the simulation-assisted calculator or traditional carbohydrate counting for prandial insulin dosing, with glucose monitored using Freestyle Libre. After four weeks, the group using the simulation-assisted calculator showed a 7% increase in time in the target glucose range (70-180 mg/dL) compared to the control (p < 0.001), along with

SUBMITTER: Builes-Montano CE 

PROVIDER: S-EPMC12615814 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature