Hepatocyte Piezo1 regulates glycogen metabolism via the FGF21-STAT3 pathway.

ABSTRACT: The metabolism of glycogen in the liver plays a crucial role in regulating blood glucose levels. Previous studies have underscored the critical involvement of Piezo1 in glucose metabolism. However, the role of Piezo1 in hepatic glycogen metabolism remain unexplored. We induced liver-specific deletion of Piezo1 in Piezo1^fl/fl mice using Cre adenovirus via tail vein injection. Compared to Piezo1^fl/fl treated with GFP adenovirus, those treated with AAV-Cre exhibited impaired glucose tolerance, elevated GYS2 and PYGL levels, and decreased FGF21 levels, implicating inhibition of the STAT3 signaling pathway. Furthermore, mice with hepatocyte-specific Piezo1 deletion (Alb-Piezo1^-/-) on a high-fat diet experienced exacerbated blood glucose levels, decreased hepatic

SUBMITTER: Tao T 

PROVIDER: S-EPMC12615880 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature