Extent of reoperation predicts survival in recurrent IDH-wildtype glioblastoma based on institutional data and individual patient data meta analysis.

ABSTRACT:

Background

Glioblastoma (GB) is the most aggressive brain tumor, characterized by rapid progression and poor prognosis. Despite initial multimodal treatment options, therapeutic options become more limited upon recurrence. Consequently, recurrent IDH-wildtype GB is associated with poor survival outcomes, with limited data to guide optimal therapeutic strategies. This study presents the largest meta-analysis to date, pooling institutional data with individual patient data (IPD), addressing progression-free survival (PFS) and overall survival (OS) from timepoint after re-resection.

Methods

Institutional data and data from literature (2016-2024) were analyzed to evaluate PFS and OS in relation to the extent of resection (EoR). Survival data from identified studies were extracte

SUBMITTER: Basaran AE 

PROVIDER: S-EPMC12615886 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature