Oral contraceptives and the risk of rheumatoid arthritis in women: A systematic review and meta-analysis.

ABSTRACT: ObjectivesThe relationship between the use of oral contraceptives and the risk of rheumatoid arthritis remains unclear. The objective of this meta-analysis was to comprehensively evaluate the association between oral contraceptive use and rheumatoid arthritis risk.MethodsA systematic search was conducted in PubMed, EMBASE, and Cochrane Library databases for cohort studies published from 1980 to July 2024. Studies were assessed for bias using the Newcastle-Ottawa Scale. Two investigators independently screened abstracts and full-text articles and graded the certainty of evidence according to the Grading of Recommendations Assessment, Development and Evaluation approach. Data were analyzed using random effects models, and publication bias was evaluated using funnel plots and Egger test. A le

SUBMITTER: Luo L 

PROVIDER: S-EPMC12615980 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature