Pathological role of immunoproteasome PSMB8 in Parkinson's disease: a link between α-synuclein aggregation and immune activation.

ABSTRACT:

Background

Parkinson's disease (PD) is characterised by α-synuclein accumulation and progressive neurodegeneration, with immune activation recognised as a key contributor. The immunoproteasome (IP), particularly its catalytic subunit PSMB8, plays dual roles in proteostasis and immune regulation, yet has an unclear role in synucleinopathies.

Methods

A total of 232 blood samples from patients with synucleinopathies (PD, multiple system atrophy [MSA], and rapid eye movement [REM] sleep behaviour disorder [RBD]), and healthy individuals were analysed for IP expression/activity in peripheral blood mononuclear cells (PBMCs) and neuronal extracellular vesicles (NEVs), and effects of IP inhibition using flow cytometry. Post-mortem human substantia nigra was examined for spatial dist

SUBMITTER: Nguyen HD 

PROVIDER: S-EPMC12616017 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature