Glucose tasting depletes intracellular calcium stores and impairs macrophage functionality.

ABSTRACT: Hyperglycemia or increased blood glucose concentrations is a characteristic and one of the diagnostic criteria for Diabetes mellitus and critically contributes to the onset of secondary diseases. We investigated the effect of hyperglycemia on macrophage activation and functionality, demonstrating enhanced priming toward inflammatory cytokines in hyperglycemic macrophages. Additionally, increased glucose concentrations depleted intracellular Ca²⁺ stores by promoting Ca²⁺ release from the ER. We identified taste receptors on macrophages as sensors for hyperglycemia, mediating Ca²⁺ release into the cytosol by activating the IP3 receptor and inhibiting SERCA. Dysregulated Ca²⁺ homeostasis correlated with taste receptor expression and hyperglyc

SUBMITTER: Schlautmann L 

PROVIDER: S-EPMC12616019 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature