Temporal dynamics of Purkinje cell-intrinsic excitability governs cerebellar systems consolidation.

ABSTRACT: Systems consolidation reorganizes newly encoded memories from cortical networks into downstream circuits. Although synaptic mechanisms are extensively characterized, the role of neuronal intrinsic excitability (IE) in this process remains relatively unexplored. Here, we utilized a cerebellum-dependent learning model to investigate the causal link between neuronal IE and memory consolidation. The optogenetic manipulation of Purkinje cells (PCs), the sole output of the cerebellar cortex, identified a crucial 90-min post-learning window during which PC-IE undergoes transient depression. Disrupting this decline by elevating PC-IE hindered long-term memory, whereas interventions outside this window did not. Elevated PC-IE spared basal ocular reflexes, indicating its role is specific to adaptive

SUBMITTER: Seo J 

PROVIDER: S-EPMC12616028 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature