Triglyceride-glucose index and risk of renal function decline and death-censored renal allograft loss in kidney transplant recipients.

ABSTRACT:

Background

Although insulin resistance is common, its significance in kidney transplant recipients remains unclear. We explored clinical implications of the triglyceride-glucose (TyG) index as a marker for unfavorable allograft outcomes in kidney transplant recipients.

Methods

A total of 6,354 kidney transplant recipients were enrolled in a multicenter prospective cohort study between May 2014 and December 2022. The TyG index was assessed between 6 and 12 months after transplantation. We evaluated the association between the TyG index and the risk of adverse kidney outcomes.

Results

The cumulative rates of ≥50% decline in estimated glomerular filtration rate (eGFR), death-censored graft survival, and major adverse kidney events differed across TyG index quartiles, wit

SUBMITTER: Lee HJ 

PROVIDER: S-EPMC12616052 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature