Macrophage depletion lowers blood pressure and reduces renal fibrosis progression in existing hypertension mice model.

ABSTRACT: Uncontrolled hypertension is a global health issue with 40 % of hypertensive patients not achieving blood pressure control with current therapies. Previously, we demonstrated renal macrophage infiltration during hypertension development with macrophage depletion leading to reduced blood pressure and renal fibrosis. However, the effect of macrophage depletion in existing hypertension has not been evaluated. We induced hypertension in mice then depleted macrophages and assessed blood pressure and renal fibrosis. Separately induced hypertension and assessed renal macrophage population and fibrosis early in hypertension. Results showed increased renal macrophage, Acta2 early in hypertension development. Macrophage depletion led to reduced blood pressure in the hypertensive mice, decreased kidn

SUBMITTER: Peter JK 

PROVIDER: S-EPMC12616062 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature