TRAF2 and NCK interacting kinase: a novel regulator of integrin α_IIbβ₃ signaling in platelets.

ABSTRACT:

Background

TRAF2 and NCK interacting kinase (TNIK) is a serine/threonine kinase member of the germinal center kinase family. Previously, in other cell types, TNIK has been shown to interact with key cytoskeletal regulatory proteins, to regulate F-actin distribution, cell polarization, and neuronal cell arborization. Proteomic studies have demonstrated TNIK is present in platelets; however, no further studies have explored if TNIK plays a role in the regulation of platelet function.

Objectives

We sought to investigate the distribution of TNIK in platelets and characterize a potential role for TNIK in platelet function.

Methods

The importance of platelet TNIK was explored using 2 structurally distinct TNIK inhibitors (KY-05009 and NCB-0846) in aggregometry, assays of gr

SUBMITTER: Bull LJ 

PROVIDER: S-EPMC12616069 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature