Melatonin attenuates cardiac oxidative stress in diabetic rats following acute exhaustive exercise.

ABSTRACT:

Introduction

Diabetes mellitus affects millions of people worldwide and there is evidence linking the increase of oxidative stress to the development of diabetic cardiomyopathy. Melatonin has been found to possess powerful antioxidant properties via modulating both enzymatic and non-enzymatic antioxidant systems.

Objective

To evaluate the antioxidant potential of melatonin on the heart of diabetic animals at basal conditions and following 2 h of strenuous exercise.

Methods

Diabetic animals were divided into two groups: non-supplemented and supplemented (melatonin). We evaluated oxidative stress biomarkers, total glutathione amount, oxidative stress index and antioxidant enzymes mRNA expression, immediately after an exhaustive exercise (IA group), and 2 h after exhaust

SUBMITTER: Nguyen C 

PROVIDER: S-EPMC12616075 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature