Distinct genetic responses to fluoxetine sertraline and citalopram in mouse cortical neurons.

ABSTRACT: Antidepressants are widely prescribed for treating major depressive disorder (MDD); however, their precise therapeutic mechanisms remain incompletely understood. A notable conundrum is the substantial heterogeneity in clinical efficacy among drugs targeting the same molecular pathway, such as selective serotonin reuptake inhibitors (SSRIs). We performed comparative transcriptome analyses of mouse cortical neuron cultures in vitro, treated with fluoxetine, sertraline, or citalopram, revealing distinct drug-specific gene expression patterns. Utilizing self-organizing map (SOM) clustering, we identified gene sets uniquely responsive to each SSRI treatment. Corresponding in vivo analyses also demonstrated drug-specific transcriptomic changes within mouse brains. Integrating both

SUBMITTER: Yamamoto H 

PROVIDER: S-EPMC12616122 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature