Quantitative T₁ and Effective Proton Density (PD*) mapping in children and adults at 7T from an MP2RAGE sequence optimised for uniform T₁-weighted (UNI) and FLuid And White matter Suppression (FLAWS) contrasts.

ABSTRACT: Quantitative T₁ and PD mapping is important for non-invasive tissue characterisation. Here, we aimed to calculate effective proton density (PD*) and quantitative T₁ relaxation maps at 7T using the MP2RAGE sequence and an analytical formula. This was applied to a short repetition time (TR_MP2RAGE) protocol developed to produce both Fluid And White Matter Suppression (FLAWS) and T₁-weighted uniform image (UNI) images. T₁ and PD* were estimated from analytical MP2RAGE signal equations for partial Fourier acquisitions. The sensitivity with respect to the TR_MP2RAGE and B₁ ⁺ effects on both excitation flip angles and inversion efficiency was evaluated. T₁ and PD* alteration with age (10-54 years) we

SUBMITTER: Dokumacı AS 

PROVIDER: S-EPMC12616151 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature