Comparison of metrics of neonatal intensive care unit antibiotic use.

ABSTRACT:

Objective

To compare temporal trends, variation, and correlations between antibiotic use metrics across U.S. neonatal intensive care units (NICUs) and assess associations with mortality.

Methods

We conducted a retrospective cohort study of 438,156 infants admitted to 272 NICUs from 2017 to 2021 using the Premier Health Database. Antibiotic use rate (AUR), days of therapy (DOT), and antibiotic spectrum index (ASI) per 1,000 patient or therapy days were calculated both cumulatively by year and at the center level. Mixed-effects models adjusted for center-level characteristics were used for all analyses.

Results

All three metrics declined over time: AUR by 16.8%, DOT by 19.0%, and ASI by 2.5%. AUR and DOT were highly correlated (r = 0.989, P < 0.001), while

SUBMITTER: Zevallos Barboza A 

PROVIDER: S-EPMC12616220 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature