Long-Term Outcomes of Young Adults With Perinatal Human Immunodeficiency Virus (HIV) Infection in the United States and Puerto Rico.

ABSTRACT:

Background

Data on mortality, clinical events, viral load (VL), and immunosuppression among young adults aging with perinatally acquired human immunodeficiency virus (YAPHIV) are limited.

Methods

Among YAPHIV ≥ 18 years in the Pediatric HIV/AIDS Cohort Study, we calculated incident mortality, CDC-C/WHO-4 rates, and proportion of person-years (PY) with elevated VL (≥200 copies/mL) and immunosuppression (CD4 < 200 cells/mm³) by age strata 18-21, 22-25, 26-29, and ≥30 years. We compared mortality rates to the US population and identified predictors of mortality/CDC-C/WHO-4 events at age ≥ 25 years.

Results

Six hundred seventeen participants had median follow-up of 6.5 years; at baseline, 63% were 18-21 years, 61% were female, 63% self-reported as Black, median

SUBMITTER: Kern L 

PROVIDER: S-EPMC12616363 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature