Analysis of treatment options and survival outcomes for patients with localized prostate cancer: a focus on androgen deprivation therapy.

ABSTRACT:

Background

Management of localized prostate cancer (PCa) remains challenging in resource-limited settings where access to surgery and radiotherapy is restricted. This study assessed the survival outcomes of patients receiving androgen deprivation therapy (ADT) alone compared with other modalities.

Methods

We retrospectively analyzed patients with localized PCa treated with ADT at Taiyuan Central Hospital of Shanxi Medical University from 2002 to 2023. Cox regression identified prognostic factors for overall survival (OS), disease-specific survival (DSS), and progression-free survival (PFS). Outcomes were compared with SEER database cohorts receiving radical prostatectomy (RP), radiotherapy (RT), or no treatment. Propensity score matching (PSM) was used to balance baseline ch

SUBMITTER: Li Z 

PROVIDER: S-EPMC12616373 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature