Effects of Dietary Sodium Modulation on Circulating Extracellular Vesicles.

ABSTRACT:

Background

Sodium is involved in osmoregulation, fluid balance, and immune system function. High sodium (HS) consumption is linked to endothelial dysfunction, hypertension, and mortality. Extracellular vesicles (EVs), nano-sized particles reflecting cellular status, could link dietary sodium to vascular and immune changes. This study aimed to characterize circulating EVs and assess their functional role on endothelial cells after dietary sodium modulation.

Methods

Fifty subjects underwent 2 dietary sodium interventions, each lasting 5 to 7 days: sodium-restriction (10-40 mmol/d, 0.23-0.92 g/d) followed by sodium-loading (intake above 180 mmol/d, 4.14 g/d). Serum EVs were isolated after each phase and analyzed using a flow cytometry bead-based platform. Bioinformatics identif

SUBMITTER: Burrello J 

PROVIDER: S-EPMC12616404 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature