Medial temporal lobe lesions reduce visual working memory precision.

ABSTRACT: Classic lesion case-control studies suggest minimal involvement of the medial temporal lobe (MTL) in visual working memory (VWM), particularly for simple stimulus features like color or orientation. However, recent intracranial recordings implicate the MTL - especially the hippocampus - in supporting VWM precision by distinguishing similar visual features to reduce representational variability during short retention intervals. Meanwhile, reports that MTL activity scales with VWM set size have raised the possibility that the MTL contributes not only to the quality but also the quantity of retained VWM content - an idea motivated by models positing a unitary memory strength metric to account for behavioral expressions of both VWM quantity and quality. To clarify the extent to which MTL lesio

SUBMITTER: Choo Y 

PROVIDER: S-EPMC12616444 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature