Transcriptome Sequencing Reveals Distinct Stress Response of Listeria monocytogenes 6179 During Logarithmic and Stationary Growth Phases.

ABSTRACT: Listeria monocytogenes is a food-borne pathogen that continues to threaten food safety by persisting in food production environments (FPEs). Its tolerance to stressors introduced in FPEs is well characterized; however, the effect of the growth phase on stress response gene expression is less understood. Here, we utilize transcriptome sequencing to analyze gene expression of the persistent L. monocytogenes strain 6179 in response to 30-min exposure to either lactic acid or oxidative stress when grown to either logarithmic or stationary growth phase. Analysis of this data revealed distinct gene expression responses to stress exposure between the two growth phases. Exposure to lactic acid (1%, pH 3.4) resulted in 1809 significant (Q < 0.05, log₂fold changes with absolute values ≥ 1

SUBMITTER: Strathman-Runyan JL 

PROVIDER: S-EPMC12616503 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature