Diffusion MRI Microstructure Markers of Changes in the Human Brain Across the Lifespan Using Constrained Spherical Deconvolution and Fixel-Based Techniques.

ABSTRACT: Understanding how the brain develops, matures, ages, and declines is one of the fundamental questions facing neuroscience. This study uses 3-tissue constrained spherical deconvolution (3T-CSD) and more recently developed fixel-based derivatives to examine the relationship between brain diffusion microstructure and chronological age. These metrics are able to quantify signal fraction measurements at the voxel-wise level from six different tissue microenvironments found in the brain: extracellular free water, intracellular isotropic, intracellular anisotropic, fiber density and cross-section, the g-ratio, and aggregate conduction velocity. This study analyzes the Nathanial Kline Institute's Rockland cohort, a large-scale community sample of brain MRI data across the lifespan (409 subjects, a

SUBMITTER: Newman BT 

PROVIDER: S-EPMC12616505 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature