A New Strategy for Treating Renal Fibrosis Based on a Drug-Food Homogeneous Formula of Traditional Chinese Medicine.

ABSTRACT: Renal fibrosis is a common pathological feature of chronic kidney disease (CKD) as it progresses to the end stage. Currently, about 10% of adults worldwide are affected by this disease. In recent years, significant progress has been made in the field of renal fibrosis treatment, with both traditional drugs and innovative therapies showing new hope. In this study, we propose a novel therapeutic strategy for renal fibrosis based on the traditional Chinese medicine concept of "medicinal and edible homology". This involves the use of a compound formulation comprising red ginseng, dandelion, and oyster shell, and evaluating its therapeutic effect on renal fibrosis through the colon administration route. Through integrated network pharmacology and molecular docking analyses, we identified AKT1,

SUBMITTER: Zitian G 

PROVIDER: S-EPMC12616506 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature