Inhalability and Bioactivity of Spray-Dried versus Pressurized Gas eXpanded Liquid Technology-Processed Yeast Beta-Glucan Microparticles for Anti-Fibrotic Therapies.

ABSTRACT: Current anti-fibrotic therapeutics for idiopathic pulmonary fibrosis (IPF) slow disease progression but are non-curative and have systemic side effects, promoting interest in therapies that can repolarize macrophages away from their pro-fibrotic phenotype. While yeast beta-glucan (YBG) offers therapeutic potential in reprogramming macrophages toward an anti-fibrotic phenotype, YBG processing must be optimized to promote inhalability while preserving its biological activity. Herein, the biological and inhalation performance of YBG processed via Pressurized Gas eXpanded liquids technology (PGX^TEC-YBG) relative to conventionally spray-dried YBG (SD-YBG) is compared. The significantly smaller size and lower density of PGX^TEC-YBG relative to SD-YBG result in a smaller aero

SUBMITTER: Dowdall N 

PROVIDER: S-EPMC12616587 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature