3D-Printed Multidimensional Bionic Mg-MC/PLGA Composite for Tailored Repair of Segmental Long Bone Defects.

ABSTRACT: The management of long bone segmental defects represents a critical challenge in orthopedic medicine. This study focuses on developing an innovative bone repair material to overcome the inherent limitations of existing solutions. The material is synthesized by incorporating magnesium into mineralized collagen to produce Mg-MC bone powder, which is then combined with polylactic acid-hydroxyglycolic acid copolymer (PLGA). Using advanced 3D printing and femtosecond laser techniques, Mg-MC/PLGA scaffolds with varying magnesium concentrations (0%, 5%, 10%, 20%) are fabricated and characterized. In vitro studies demonstrate that the 5% Mg-MC/PLGA scaffold exhibits superior cytocompatibility, cellular proliferation, migration, angiogenesis, and osteogenic activity, supported by elevated expressio

SUBMITTER: Liu S 

PROVIDER: S-EPMC12616600 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature