Multiscale Profiling of Nanoscale Metal-Organic Framework Biocompatibility and Immune Interactions.

ABSTRACT: The clinical translation of metal-organic frameworks (MOFs) - a promising class of porous materials for nanomedicine - is hindered by a poor understanding of their complex interactions with the immune system and in vivo immunotoxicity. To address this gap, a hierarchical "Safety-by-Design" pipeline is established and validated, integrating machine learning (ML) with ex vivo human blood studies and targeted in vivo models. This multi-stage workflow enables the systematic profiling of MOF immunotoxicity, de-risking their development. The power of this approach is demonstrated using four clinically relevant MOFs - NU-901, PCN-222, UiO-66, and ZIF-8 - revealing distinct, framework-dependent immune fingerprints. The initial in silico screening correctly flagged NU-901 and ZIF-8 as potential haz

SUBMITTER: Zhuang Y 

PROVIDER: S-EPMC12616609 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature