Dogs with sudden acquired retinal degeneration syndrome have evidence of a hypercoagulable state and decreased clot turnover.

ABSTRACT:

Objective

To evaluate plasma from dogs with sudden acquired retinal degeneration syndrome (SARDS) for coagulability, extent of clot turnover, and plasminogen activator inhibitor-1 (PAI-1) concentrations.

Methods

Archived (2016 to 2017) or fresh (2023 to 2024) citrated plasma was collected (jugular venipuncture) at a university clinic from dogs with confirmed SARDS and controls (age, breed, and sex matched to a dog with SARDS). Light absorbance fibrinolysis assay assessed clot formation (clot formation velocity, peak optical density [POD], and area under the curve [AUC]) and degradation (percent clot lysis at 30 to 60 minutes, clot lysis velocity). Concentrations of PAI-1 were measured (ELISA). Results were analyzed with the Wilcoxon signed rank test, Spearman correlation, an

SUBMITTER: Heyward JL 

PROVIDER: S-EPMC12616641 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature