Clinical course and outcomes of patients with anti-interferon-gamma autoantibody-associated adult-onset immunodeficiency: an observational cohort study.

ABSTRACT:

Background

Anti-interferon-gamma autoantibody (anti-IFN-γ-auto-Abs)-associated adult-onset immunodeficiency (AOID) syndrome presents with variable clinical manifestations, and long-term outcome data and natural history remain limited.

Materials and methods

This single-center study utilized a disease registry of AOID patients (≥18 years) at Siriraj Hospital, Bangkok, Thailand. Clinical outcomes (survival, death, loss to follow-up) as of November 20, 2024 and disease status (remission, non-remission) at each visit were analyzed.

Results

A total of 65 patients were recorded over an eight-year period between 2017 and 2024. The mean age of all patients was 56.4 years, and 66% were female. At initial presentation, 95 opportunistic infections were isolated from 61 pat

SUBMITTER: Angkasekwinai N 

PROVIDER: S-EPMC12616649 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature