Association of CXCL16 in aseptic loosening following total hip arthroplasty and its effect on bone metabolism: a case-control study.

ABSTRACT:

Background

Aseptic loosening commonly leads to surgical failure and revision arthroplasty after total hip arthroplasty (THA). C-X-C motif chemokine ligand 16 (CXCL16), a chemokine involved in various inflammatory and immune responses, has been implicated in bone metabolism. This single-institution study investigated the association between CXCL16 and aseptic loosening following THA.

Methods

We compared 100 patients who underwent revision THA due to aseptic loosening (experimental group) to 100 patients who underwent primary THA for femoral neck fracture or congenital hip dysplasia (control group). Immunohistochemistry and RT-PCR were used to assess CXCL16 expression at the protein and mRNA levels. Double immunofluorescence staining determined the RANKL/OPG ratio in periartic

SUBMITTER: Zhu L 

PROVIDER: S-EPMC12616655 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature