Higher soluble CD8 correlates with poor prognosis in hospitalized pulmonary infection patients.

ABSTRACT:

Objectives

Pulmonary infections pose significant challenges in accurate prognosis due to the lack of reliable biomarkers. This study aims to explore the prognostic potential of soluble CD4 (sCD4) and sCD8 for adverse outcomes in hospitalized pulmonary infection patients.

Methods

This study enrolled 112 hospitalized pulmonary infection patients and 62 healthy controls (HCs). Hospitalized patients were grouped into survivors (n = 87), who recovered and were discharged, and non-survivors (n = 25), who either died or discontinued treatment due to severe conditions. Plasma sCD4 and sCD8 levels were quantified by ELISA. T cell subsets were determined using flow cytometry. IL-6 and procalcitonin (PCT) levels were detected using electrochemiluminescence, and C-reactive

SUBMITTER: Li Y 

PROVIDER: S-EPMC12616659 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature