<i>Latilactobacillus sakei</i> CNTA 173 Reduces Fat Mass by Modulating Sphingolipid Metabolism in Diet-Induced Obese Wistar Rats.

ABSTRACT: The use of probiotics with health-promoting activities has emerged as a strategy to combat specific hallmarks of obesity, such as excessive fat accumulation and associated inflammation. Here, we investigate the physiological and metabolic effects of Latilactobacillus sakei CNTA 173 (10⁹ CFU/day) in diet-induced obese Wistar rats. Biochemical, 16S microbiota, untargeted metabolomic, and gene expression analyses were performed, as well as an in vivo toxicological study to demonstrate its safety. Probiotic-supplemented rats showed reduced adiposity, an improved inflammatory marker profile, and enhanced glucose tolerance, partly by modulating fecal microbiota composition and regulating the production of novel plasma metabolites, specifically sphingolipid-derived mediators suc

SUBMITTER: Goyache I 

PROVIDER: S-EPMC12616695 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature