Release and Reuptake Sites for Norepinephrine Are Differently Distributed Across Layers of the Primary Visual Cortex in Macaque Monkeys.

ABSTRACT: Norepinephrine (NE) is released in cortex by axons arising from the locus coeruleus (LC). The cortical innervation patterns from LC have been mapped previously using antibodies directed against the vesicular synthetic enzyme for NE, dopamine β-hydroxylase (DBH), which provides information about putative release sites. We sought to quantify putative NE reuptake sites by immunolabeling the norepinephrine transporter (NET), focusing on the primary (V1) and secondary (V2) visual cortex of macaque monkeys. We used stereological methods to determine the density of axon segments immunoreactive for NET (NET+ segments) in V1 and V2, and non-stereological methods to compare the laminar distribution of NET+ segments and to compare the distribution of NET+ segments in V1 with segments immunoreactive f

SUBMITTER: Roach C 

PROVIDER: S-EPMC12616712 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature