The non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio is associated with early onset type 2 diabetes with NAFLD: a cross-sectional study in China.

ABSTRACT:

Background

The non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) is a novel composite lipid biomarker associated with metabolic diseases. This study aims to explore the potential relationship between early-onset type 2 diabetes mellitus combined with NAFLD and NHHR.

Methods

A total of 1,158 patients with type 2 diabetes were enrolled and categorized by age at onset into the early-onset type 2 diabetes (EOT2D) group (260 cases, <40 years) and the late-onset type 2 diabetes (LOT2D) group (898 cases, ≥40 years). The EOT2D group was further subdivided into those with NAFLD (136 cases) and those without NAFLD (124 cases). Multivariate logistic regression assessed the association between NHHR and EOT2D, as well as EOT2D combined with NAF

SUBMITTER: Wu N 

PROVIDER: S-EPMC12616743 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature