MRanalysis: a comprehensive online platform for integrated, multimethod Mendelian randomization and associated post-GWAS analyses.

ABSTRACT:

Background

Mendelian randomization (MR) is a powerful epidemiological method for inferring causal relationships between exposures and outcomes using genome-wide association study (GWAS) data. However, its adoption is limited by inconsistent data formats, lack of standardized workflows, and the need for programming expertise. To address these challenges, we developed MRanalysis, a user-friendly, web-based platform for integrated MR analysis, and GWASkit, a standalone tool for GWAS data preprocessing.

Results

MRanalysis provides a comprehensive, no-code workflow for MR analysis, including data quality assessment, power estimation, single-nucleotide polymorphism to gene enrichment, and visualization. It supports univariable, multivariable, and mediation MR analyses through an i

SUBMITTER: Xing A 

PROVIDER: S-EPMC12616851 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature