Succinic acid-driven gut-fat axis orchestrates abdominal fat deposition in chickens via adipocyte-macrophage crosstalk.

ABSTRACT:

Background

Excessive abdominal fat in broilers not only reduces feed efficiency and increases processing costs but also raises environmental concerns. This pathological overaccumulation results from complex metabolic dysregulation across multiple organs. While current research largely centers on adipogenesis within adipose tissue, a comprehensive understanding of the cross-organ regulatory factors influencing this process remains elusive.

Results

Here, we employed a high-fat diet (HFD) model and multi-omics approaches to investigate cross-organ regulatory mechanisms underlying abdominal fat deposition in broilers. Our results demonstrated that HFD not only promoted fat accumulation but also altered meat quality traits. Through 16S rRNA amplicon sequencing, we identified sign

SUBMITTER: Chen J 

PROVIDER: S-EPMC12616907 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature