Human collagen III mRNA therapy for effective skin rejuvenation.

ABSTRACT:

Background

Skin photoaging leads to the deterioration of dermal collagen and overall skin integrity, resulting in visible signs of aging, particularly around the eye. Collagen III plays a pivotal role in maintaining skin elasticity and facilitating proper collagen fibril organization. Messenger RNA (mRNA)-based therapeutics present a novel alternative for addressing these limitations by enabling the localized production of full-length, biologically active proteins.

Methods

This study evaluates the therapeutic effects of human collagen III (hCOL3A1) mRNA on UVB-induced skin photoaging using in vitro and in vivo models. In vitro, human fibroblasts were used to assess oxidative stress, senescence, apoptosis, proliferation, and migration. In vivo, a UVB-induced murine photoaging

SUBMITTER: Zhang J 

PROVIDER: S-EPMC12616958 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature