Fibroblast activation protein (FAP)-mediated promotion of metastasis via the FN1-TGFβ axis and immune suppression in aggressive thyroid cancer.

ABSTRACT:

Background

Treatment options of aggressive thyroid carcinoma (TC) is limited due to its aggressiveness. Therefore, increased knowledge of the role of tumor intrinsic immune escape mechanisms and the microenvironment contributing to metastases formation is essential to improve the patients' outcome. These include extracellular matrix (ECM) components, cancer-associated fibroblasts (CAFs) and the expression of the fibroblast activation protein (FAP) known to be involved in immune evasion, disease progression and a worse prognosis of thyroid carcinoma (TC) patients.

Methods

The Cancer Genome Atlas (TCGA) and Human Protein Atlas datasets of TC specimens as well as tissue microarrays (TMA) consisting of 187 TC samples were analyzed for marker expression and immune cell infiltrati

SUBMITTER: Udinotti M 

PROVIDER: S-EPMC12616960 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature