Cerebral small vessel disease score associated with brain hypoperfusion predicts cognitive decline: a longitudinal study.

ABSTRACT:

Background

This study aimed to investigate the association between cerebral small vessel disease (CSVD) score and cerebral blood flow (CBF) at baseline in cognitively intact older adults and to explore whether the total CSVD burden score serves as an imaging marker that can predict cognitive impairment in aging populations.

Methods

MR images acquired from 509 participants with normal cognition were analyzed to evaluate the association between the total CSVD burden score and CBF. Structural scans, pseudo-continuous arterial spin labelling (pCASL) for CBF quantification, and 3D T1-weighted sequences were obtained. CSVD burden scores were rated using a validated 5-point scale by assessing white matter hyperintensity, lacunes, perivascular spaces, and microbleeds. Participants u

SUBMITTER: Zhang X 

PROVIDER: S-EPMC12616964 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature