Genetic mapping in collaborative cross mouse strains identifies loci that affect initial sensitivity to cocaine.

ABSTRACT:

Rationale

Cocaine use disorder (CUD) is a significant health concern that has devastating impacts on affected individuals and society. There are currently no approved therapies to treat CUD due, in part, to significant gaps in our knowledge about the underlying factors that increase risk. Individual genetic differences contribute to CUD risk. Identifying specific genetic mechanisms that increase risk could reveal novel targets for treatment and prevention.

Objectives

We identified two Collaborative Cross (CC) strains, CC004/TauUncJ (CC004) and CC041/TauUncJ (CC041), that differ significantly for locomotor response and self-administration of cocaine. In the current study, we used mapping crosses generated from both strains to identify genetic loci that are associated with beh

SUBMITTER: Schoenrock SA 

PROVIDER: S-EPMC12617008 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature