Maternal gut microbiota and placenta-derived tissues microbes are important for initial gut microbial colonization in infants.

ABSTRACT:

Background

Early infant gut microbiota colonization, influenced by various factors, significantly affects future growth and development. However, results related to how the initial microbial ecology is established in the infant gut remain inconsistent.

Results

In this study, we collected maternal and infant feces, vaginal secretions, placental tissues, breast milk, amniotic membrane tissues, umbilical cord blood, and breast skin for homology comparisons and for exploring the main sources of infant intestinal microbiota. Our results revealed that early infant gut microbiota originated mainly from the vertical transmission of maternal microbiota, and that vaginal microbiota did not affect infant gut microbiota colonization. Microbiota was detected in the placenta, supporting t

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC12617009 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature