Feasibility and Safety of Cytosorb Application in Patients With Acute Liver Failure.

ABSTRACT:

Background and aims

Acute liver failure (ALF) is a rare, life-threatening condition with high mortality and limited therapeutic options beyond liver transplantation. Cytosorb adsorber can be easily applied to continuous renal replacement therapy (CRRT) and potentially support liver function by removing bilirubin and cytokines.

Methods

This retrospective single-centre study included all ALF patients admitted to the intensive care unit (ICU) at the Division of Gastroenterology and Hepatology of the Vienna General Hospital from 2012 to 2025 receiving CRRT.

Results

Twenty-eight ALF patients (median SOFA 11, SAPS II 43) were included, with high incidences of vasopressor use (82.1%) and invasive ventilation (85.7%). Fourteen received adjunctive Cytosorb therapy. Complicatio

SUBMITTER: Patrick H 

PROVIDER: S-EPMC12617026 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature