Genetic Liability to Bone Mineral Density and Functional Outcome After Ischemic Stroke.

ABSTRACT:

Background and objectives

An increasing amount of research indicates that bone mineral density (BMD) could impact the functional outcome after ischemic stroke (FOAIS). However, the specific connection between BMD and FOAIS is still not clear. Hence, we utilized the Mendelian randomization method to examine the genetic predisposition to BMD in connection with FOAIS.

Methods

Instrumental variables for BMD, heel bone mineral density T score (HBMDTS), and lumbar spine bone mineral density (LSBMD) were identified from genome-wide association study data of individuals with European ancestry. The study on FOAIS data came from European ancestry patients and was carried out by the Genetics of Ischemic Stroke (IS) Functional Outcome network. The inverse variance weighted method was em

SUBMITTER: Fan D 

PROVIDER: S-EPMC12617269 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature