Theranostic Probiotic Engineered Living Materials That Dynamically Respond to Inflammation Markers.

ABSTRACT: The development of smart, implantable devices localized at the site of inflammation to conditionally and proactively combat active inflammation for inflammatory bowel disease (IBD), has the potential to transform the patient's quality of life compared to conventional treatment modalities. Engineered probiotic organisms can enable dynamic production of therapeutic compounds in response to inflammatory biomarkers. However, delivery and localization of these engineered organisms to the site of inflammation requires their integration into a material or device that sustains their viability and metabolic activity. To this end, a 3D printed engineered living material (ELM) is developed using an engineered probiotic organism (E. coli Nissle 1917) with genetic circuits to sense biomarkers for infla

SUBMITTER: Altin-Yavuzarslan G 

PROVIDER: S-EPMC12617286 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature